<div class='quotetop'>QUOTE (graatch @ May 24 2010, 09:44 PM) <{POST_SNAPBACK}></div><div class='quotemain'>Of course, enough of a sedative can knock any system out -- or, perhaps, a missing critical section might stop a machine from working -- but the system still might be composed by and work with multiple mechanisms on the larger emergent scale that operates when things are working, when something particular isn't being precisely targeted and negated, you know?

For example I think enough GABA agonism would block DA release too, but I wouldn't conclude that lack of GABA the 'entire' positive mediator of dopamine release. [img]style_emoticons/<#EMO_DIR#>/tongue.gif[/img]</div>
Yes i know what your saying here and i agree. I just wanted to know why dopaminergics werent reinforcing without 5HT2A/Alpha1B and yeah it appears they arent dopaminergics anymore at all without the those.