ReBoot™ - 7-Keto-DHEA & 7-OH-DHEA
Originally posted at Advanced Muscle Science Lab
Reboot is one of the next new stars from ForeRunner Labs. Reboot is a product designed to be used after a prohormone cycle to quickly and efficiently recover your hormonal levels back into optimal ranges. It can also be used anytime in between cycles to optimize hormones levels, including testosterone, estrogen, and cortisol. We previously gave you a look inside the fourth component of the product which contains both cystine and theanine. Together these amino acids have been shown to strengthen the immune system of weight training males, amongst other benefits - Cystine and Theanine Research Compilation. While the finished label is yet to be released, we can tell you that it contains a cortisol management system known as Cortisolvent™. Cortisolvent™ contains a blend of both 7-Keto-DHEA, as well as 7-OH-DHEA (as a 50/50 alpha/beta isomer split). Typically you see one or the other within a product, but we felt that the best approach was to use both forms, to create an even cascade of cortisol modulation. In addition, each has been validated to have slightly different effects in males (11β-HSD Type 1 competitive inhibition, weight loss, and thyroid output) as you will learn in the following paragraphs.
Institute of Endocrinology in Prague
Earlier this year an interesting study was completed to determine whether 7-Keto-DHEA and 7-OH-DHEA (both alpha and beta isomers) natural levels correlated to various measures of body weight and fat mass in teenage boys and girls. All three components of Cortisolvent™are produced naturally in your body from adrenal output. When you supplement Reboot and thus Cortisolvent™ you will increase the serum levels of each leading to a greater effect than you would without supplementing. These levels are typically at their highest in our younger years, which is why researchers in Prague chose this sample group (teenagers). They had four groups and split them up based on several measures, but essentially the final groups were lean boys (average body fat of 11%), obese boys (average body fat of 32%), and two groups of similar nature with girls. They took blood samples after a fasting period, and then measured the blood serum levels of each compound found in Cortisolvent™. They compared the results in a statistical format to determine what differences circulating levels of 7-OH/Keto-DHEA correlate with various measures of body composition.
In the boys they found that circulating levels of 7α-OH-DHEA were higher in the obese boys compared to the lean boys. You might think this was an odd finding, but the researchers did not, and state the following:
"The increase of 7α-OH-DHEA may be a result of the increased production and conversion of 7-oxo-DHEA as a substrate for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and thus decreasing the concentration of cortisol on account of cortisone. "
In simpler terms this was the body up-regulating adrenal output in an attempt to try and limit cortisol levels, which are associated with insulin resistance, visceral fat accumulation, hypertension, and high cholesterol. Although it was not statistically significant the lean boys also had lower blood levels of 7-Keto-DHEA, and 7β-OH-DHEA. Suggesting that they had less stress overall and less of a reason to produce more adrenal output. Since this was a correlation study we do have to make some assumptions, particularly because the subject group was also younger than normal. Still we believe that had they measured actual cortisol, and cortisone serum levels you would have still found a lesser degree of serum cortisol in the lean individuals. In fact this has previously been reported in research comparing lean, obese, young, and old cortisol levels in men. They found cortisol production rate was increased as body weight increased. Further suggesting the usefulness of supplementing a product like Cortisolvent™to aid in the battle of weight management and stress induced inflammation, and more importantly post cycle therapy recovery.
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L., El Kihel. "Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports." Steroids. (2012): 10-26.
Purnell JQ, Brandon DD, Isabelle LM, Loriaux DL, Samuels MH. "Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women." J Clin Endocrinol Metab. (2004): 281-7.