Just wondering what people's experiences if any have been with D-Phenylalanine. I've been taking 500-1000mg/day for the past 6 months and have been feeling pretty good, I think i'm definitely seeing a good response to it. DL-Phenylalanine is ok but makes me sleepy. D-Phenylalanine seems really clean and hardly noticable. I checked out a few old books from the UCSF Library and read about some studies done in Argentina on D-Phenylalanine in the 1970s and 1980s..very interesting, it was trialed as low as 100-200mg in depression and saw really solid results. THese were large scale trials, couple of hundred in one of them.
The MOA seems to be that D-PA somehow increases PEA concentrations. That's why I'm taking it. But is that true? How does it do so? I had a great response to PEA two years ago, but it turned on me because of it's horrible pharmacokinetics...i ended up addicted and takign huge quantities of it. With D-PA I don't feel the acute euphoria. Does D-PA actually increase endorphins too, like people say it does? Would this have any effect on depression?
Why don't we see higher-dose D-Phenylalanine used more frequently for depression?