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  1. #1
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    Default Coffee May Keep Depression Away

    Medscape: Medscape Access



    September 26, 2011 — Risk for depression may decrease as coffee consumption increases, new research suggests.
    In a 10-year cohort study of more than 50,000 older women, investigators found that compared with those who drank 1 cup or less of caffeinated coffee per week, those who drank 2 to 3 cups per day had a 15% decreased risk for depression, and those who drank 4 cups or more had a 20% decreased risk.
    "This is one of the first major studies to look to this relationship," lead author Michel Lucas, PhD, RD, epidemiologist/nutritionist at Harvard School of Public Health in Boston, Massachusetts, told Medscape Medical News.
    Dr. Michel Lucas

    "People have often worried that drinking caffeinated coffee might have a bad effect on their health, but there is more and more literature, including this study, showing that caffeine may not have the detrimental effect previously thought," said Dr. Lucas.
    The investigators note that because this was an observational study, it did not prove causality and "only suggests the possibility" of a protective effect.
    "Further investigations are needed to confirm [the findings] and to determine whether usual caffeinated coffee consumption can contribute to depression prevention," they write.
    Still, Dr. Lucas said that it might be okay for clinicians to recommend increasing a patient's coffee intake.
    "If depressed patients are refraining themselves to 1 coffee per day because they think that's all they should have, why not try suggesting they drink more, as long as it doesn't go over 4 cups a day? We still need a large randomized controlled trial to look at this effect, but as long as it's not over a certain amount, upping the intake shouldn't hurt, and may be helpful."
    The study is published in the September 26 issue of the Archives of Internal Medicine.
    World's Most Used Stimulant
    "Caffeine is the world's most widely used central nervous system stimulant, with approximately 80% consumed in the form of coffee, " write the researchers.

    They note that although few prospective studies have looked at the link between coffee consumption and depression, a few cohort studies have found a "strong inverse association" between coffee consumption and suicide.
    However, a study from Finland ( Eur J Epidemiol. 2000;16:789-791) found that although the risk for suicide decreased progressively for those consuming up to 7 cups of coffee per day, the risk started increasing when consumption went over 8 cups a day.
    "It was surprising to us that more studies on caffeine and depression haven't been done. People who drink coffee know that it may give more energy, and we know that caffeine has an impact on the brain and on serotonin, which has been associated with depression. We wanted to explore these associations by comparing women who drink more coffee to those who drink less," said Dr. Lucas.
    The US Nurses' Health Study began in 1976 with 121,700 women between the ages of 30 and 55 years at enrollment. Updated information on lifestyle and medical history are provided every 2 years through mailed questionnaires.
    For this analysis, the investigators examined data on a cohort of 50,739 of the study's participants who did not have any depressive symptoms in 1996 (baseline for this analysis) and were followed-up through June 2006.
    In addition to evaluating both caffeinated and decaffeinated coffee consumption, the women supplied information on their use of tea, caffeinated and decaffeinated sodas, and chocolate.
    Incident or clinical depression "was defined as self-reported physician-diagnosed depression and antidepressant use," report the researchers.
    Significant Inverse Effect
    Results showed that 2607 incident cases of depression were found during the 10 years of follow-up.
    An overall "inverse, age-adjusted, dose-response relationship was observed between caffeinated coffee and depression risk (P for trend = .03)," write the investigators.
    "Further adjustment for alcohol intake did not materially affect the results," they add.
    The women who consumed 2 to 3 cups of caffeinated coffee per day had a 0.85 relative risk (RR) for depression (95% confidence interval [CI], 0.75 - 0.95), and those who drank 4 or more cups a day had an RR of 0.80 (95% CI, 0.64 - 0.99; P < .001 for both) compared with those who drank or 1 or fewer cups per week.
    In addition, the participants in the highest of the 5 caffeine consumption categories (550 mg/day or more) had an RR of 0.80 (95% CI, 0.68 - 0.95; P = .02) compared with the women in the lowest category (100 mg/day or less).
    Because only 0.52% of the women drank 6 or more cups of caffeinated coffee per day, the effects of very high consumption were not able to be addressed in this study.
    Decaffeinated coffee, caffeinated tea, sugared soft drinks, and chocolate were not significantly associated with depression risk.
    Dr. Lucas noted that these factors were examined in the women who used them and not coffee as their main source of caffeine consumption, and because their numbers were relatively small, it may have affected the results.
    Overall, this large prospective cohort study of older women (mean age, 63 years at baseline) showed that "risk of depression decreased in a dose-dependent manner with increasing consumption of caffeinated coffee," write the investigators.
    Important Contribution
    "This study makes an important contribution because it is the first large-scale study to look at this issue in women, and they focused on mental health aspects, as opposed to previous work which has focused on other health conditions," Seth Berkowitz, MD, assistant professor of clinical medicine in the Division of General and Internal Medicine at the University of California, San Francisco, told Medscape Medical News.
    Dr. Berkowitz, who is also on the editorial board for the Archives of Internal Medicine, writes in an accompanying editor's note that past research has found no significant effects of caffeine on cardiovascular disease, modest decreases in markers of inflammation, and no or modest protective effects in certain malignant neoplasms.
    "Taken together, these results reassure coffee drinkers that there seem to exist no glaringly deleterious health consequences to coffee consumption," he writes.
    Dr. Berkowitz told Medscape Medical News that people often say that caffeine gives them more energy or helps them to concentrate more. However, "it is important to quantify in a scientific way" what the effects are on mental activities.
    "As clinicians we want to make sure that people aren't doing things that will have them come to harm. And we're looking for things that we may be able to add that can be of benefit. I think in this case, this study adds to the body of evidence that there isn't much harm in coffee consumption. But I don't think we're at the point where we can say, 'drink coffee so you won't get depressed,' because that's not how the study was designed," he said.
    "Still, if your patients have questions or are wondering if drinking coffee is bad for them, I think you can provide some assurance that, at least up to the amounts examined here, it doesn't seem to be causing a lot of problems. If they are feeling like it helps them, they should enjoy it in good health."
    The study was supported by grants from the National Institutes of Health and from the National Alliance for Research on Schizophrenia and Depression. In addition, Dr. Lucas received a fellowship from the Fonds de recherche en santé du Québec. The study authors and Dr. Berkowitz have disclosed no relevant financial relationships.
    Arch Intern Med. 2011;171:1571-1578. Abstract

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    makes that 3+ dollars I spend a day at starbucks not feel as bad

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    minus the anxiety and stomach butterflies it would be perfect!

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    Fucking women works as well...

    SpringerLink - Archives of Sexual Behavior, Volume 31, Number 3

    In a sample of sexually active college females, condom use, as an indirect measure of the presence of semen in the reproductive tract, was related to scores on the Beck Depression Inventory. Not only were females who were having sex without condoms less depressed, but depressive symptoms and suicide attempts among females who used condoms were proportional to the consistency of condom use. For females who did not use condoms, depression scores went up as the amount of time since their last sexual encounter increased. These data are consistent with the possibility that semen may antagonize depressive symptoms and evidence which shows that the vagina absorbs a number of components of semen that can be detected in the bloodstream within a few hours of administration.
    I think this should be one of the many reasons girls should go on 'The Pill', they become happier, and so do we!
    My personal neuroscience weblog, you should check it out: The Illuminated Brain - A Weblog on Neuroscience

    "It is a capital mistake to theorize before one has data. Insensibly one begins to twist facts to suit theories, instead of theories to suit facts." - Sherlock Holmes

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    happy cummings baby!

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    Quote Originally Posted by kassem23 View Post
    Fucking women works as well...

    SpringerLink - Archives of Sexual Behavior, Volume 31, Number 3



    I think this should be one of the many reasons girls should go on 'The Pill', they become happier, and so do we!
    Except that the pill changes women's sexual preferences and reduces their libido (not in all cases), as well as increasing insulin resistence and decreasing LBM. IUDs might be a better option.

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    Quote Originally Posted by DeGenisis View Post
    Except that the pill changes women's sexual preferences and reduces their libido (not in all cases), as well as increasing insulin resistence and decreasing LBM. IUDs are a better option.
    fixed

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    Also, is there anything coffee doesn't do?

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    Quote Originally Posted by DeGenisis View Post
    Also, is there anything coffee doesn't do?
    I only wish I didn't get any heartburn from coffee.

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    Junior Member MindlessWork's Avatar
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    Quote Originally Posted by AynRandFit View Post
    makes that 3+ dollars I spend a day at starbucks not feel as bad
    At least cheaper than anti-deps though. I noticed coffee has had a beneficial effect on my moods

  11. #11
    Senior Member kassem23's Avatar
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    Quote Originally Posted by FunkOdyssey View Post
    fixed
    Whatevs.
    My personal neuroscience weblog, you should check it out: The Illuminated Brain - A Weblog on Neuroscience

    "It is a capital mistake to theorize before one has data. Insensibly one begins to twist facts to suit theories, instead of theories to suit facts." - Sherlock Holmes

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    Senior Member methodice's Avatar
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    Oh yeh who was that guy who asked what drugs are like caffeine as it anti-depresses him. It was a thread bout 2 months ago.
    <span style="color:#FF0000">Latest tube recs</span>: <span style="color:#0000FF">TP?</span> http://www.youtube.com/watch?v=5-i1cJh7L6I
    <span style="color:#FF0000">The last civilized bastion of truth and scientific reason declares you don't need to workout, just have good nutritional habits. The majority of us here are drug addicts and/or mentally disturbed, we also pretend to train but in reality we spend our time buzzing on adderall and masturbating to homosexual monkey porn</span>

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    Default coffee

    Quote Originally Posted by anito View Post
    minus the anxiety and stomach butterflies it would be perfect!
    it may lessen your tension and depression upto a certain level
    loollee

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    Could that be due to testosterone?

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    Anyway, back to cawfee

    The Body Odd - Coffee buzz protects brain from Alzheimer's

    Now, caffiene antagonises the Adenosine A2 receptor. This is in a relationship with a number of other neurotransmitters, one of which being antagonistic with dopamine D2 receptors.

    Adenosine A2 is pro-inflammatory. There are a few good posts around here on this interaction - try a search on Modafinal and Adenosine A2.

    But it may not be as simple as this:

    Mystery ingredient in coffee boosts protection against Alzheimer's disease, study finds

    "Caffeinated coffee provides a natural increase in blood GCSF levels," said USF neuroscientist Dr. Chuanhai Cao, lead author of the study. "The exact way that this occurs is not understood. There is a synergistic interaction between caffeine and some mystery component of coffee that provides this beneficial increase in blood GCSF levels."
    The researchers would like to identify this yet unknown component so that coffee and other beverages could be enriched with it to provide long-term protection against Alzheimer's.
    In their study, the researchers compared the effects of caffeinated and decaffeinated coffee to those of caffeine alone. In both Alzheimer's mice and normal mice, treatment with caffeinated coffee greatly increased blood levels of GCSF; neither caffeine alone or decaffeinated coffee provided this effect. The researchers caution that, since they used only "drip" coffee in their studies, they do not know whether "instant" caffeinated coffee would provide the same GCSF response.
    Unfortunately, it appears they only studied caffeinated/decaffeinated coffee and caffeine - they didn't study decaffeinated coffee + added caffeine.

    This would have been the key. It is likely that the synnergistic effect is obtained via polyphenols coupled with the stimulant, anti-inflammatory effect of caffeine at A2 receptors in the brain, but it could be down to another molecule extracted with the caffeine - a caffeine like molecule.

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    Not buying this.

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    Interesting. I hate coffee, and I suffer from depression. Not sure it would be a reason to start drinking the stuff, but interesting indeed.

    As for the other topic, there could be some truth to that.

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    There are many interesting studies on the health benefits of coffee, I started drinking it for this reason. However, once I started drinking coffee (1-2 cups of black coffee per day) I noticed my sleep quality was significantly impaired. As soon as I came off the coffee my sleep returned to normal.

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    Quote Originally Posted by AynRandFit View Post
    makes that 3+ dollars I spend a day at starbucks not feel as bad
    So true!

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    Still doesn't change my opinion. Would have to see more research on it. Coffee doesn't do it for me; the taste or as a stimulant. Maybe I'm just to full of energy all the time :P

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