User Tag List

Results 1 to 4 of 4
  1. #1
    Senior Member Marc McDougal's Avatar
    Join Date
    Aug 2003
    Location
    Kansas
    Posts
    2,860
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default


    Am J Physiol Regul Integr Comp Physiol. 2009 Jan 28. [Epub ahead of print]

    COX-2 inhibitor reduces skeletal muscle hypertrophy in mice.

    Anti-inflammatory strategies are often used to reduce muscle pain and soreness that can result from high-intensity muscular activity. However, studies indicate that components of the acute inflammatory response may be required for muscle repair and growth. The hypothesis of this study was that cyclooxygenase (COX)-2 activity is required for compensatory hypertrophy of skeletal muscle. We used the synergist ablation model of skeletal muscle hypertrophy, along with the specific COX-2 inhibitor NS-398, to investigate the role of COX-2 in overload-induced muscle growth in mice. COX-2 was expressed in plantaris muscles during compensatory hypertrophy, and was localized mainly in or near muscle cell nuclei. Treatment with NS-398 blunted the increases in mass and protein content in overloaded muscles compared to vehicle-treated controls. Additionally, the COX-2 inhibitor decreased activity of the urokinase type plasminogen activator, macrophage accumulation, and cell proliferation, all of which are required for hypertrophy after synergist ablation. Expression of insulin like growth factor-1 and phosphorylation of Akt, mTOR and p70S6K were increased following synergist ablation, but were not affected by NS-398. Additionally, expression of Atrogin-1 was reduced during hypertrophy, but was also not affected by NS-398. These results demonstrate that COX-2 activity is required for skeletal muscle hypertrophy, possibly through facilitation of extracellular protease activity, macrophage accumulation, and cell proliferation. Key words: muscle growth, non-steroidal anti-inflammatory drug, inflammation, macrophage.

    PMID: 19176887




    Body of Evidence Blog



    "If you're going to be crazy, you have to get paid for it or else you're going to be locked up." -HST

  2. #2
    Senior Member
    Join Date
    Nov 2006
    Posts
    4,748
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    Several human studies seem to show no effect to enhanced hypertrophy / strength gains with moderate dose COXIs. I wonder why the difference? Dosage?

  3. #3
    Senior Member
    Join Date
    Nov 2003
    Posts
    406
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    for hypertrophy, does that mean I need to stop taking curcumin (COX-2) and the likes( finds it helps with DOMS) right after exercise?

  4. #4
    Senior Member
    Join Date
    Aug 2005
    Posts
    6,362
    Mentioned
    0 Post(s)
    Tagged
    0 Thread(s)

    Default

    yes but what does it do wrt sustained aerobic or 'anaerobic' types of exercise?

    COX-2 is expressed in response to tissue stresses via the membrane, therefore it will always be a responder to physiological stress.

    Omega 3 concentration in the membrane however serves up feedbacks that regulate it. Remember that AA is used often in body-building industry, naturally present in eggs and human milk for facilitating growth? Of course it is in an antagonistic relationship in some key regards through these enzymes, with EPA.

    Difference seems to be that agents like O3 may increase aerobic type adaptations verses power. This is going to be through a whole plethora of effects including actions directly on PPAR subtypes.
    ------



    These ideas are released under a Creative Commons Share and Share alike license

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Similar Threads

  1. Knowledge required, please...
    By NewRevolution in forum Supplements Forum
    Replies: 3
    Last Post: October 11th, 2005, 09:25 PM
  2. Is Fat intake Required to be in ketosis?
    By maple626 in forum Supplements Forum
    Replies: 9
    Last Post: April 27th, 2005, 01:20 AM
  3. fat required for ketosis?
    By maple626 in forum Diet & Nutrition Forum
    Replies: 2
    Last Post: April 22nd, 2005, 10:29 AM
  4. refeed required? or diet brake
    By champs in forum Diet & Nutrition Forum
    Replies: 8
    Last Post: February 14th, 2005, 03:16 PM
  5. Are Signatures required for drugs-one orders?
    By brendan6787 in forum Training Forum
    Replies: 16
    Last Post: December 25th, 2004, 09:24 PM

Bookmarks

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •