I obviously do not belong in this forum, but I hope that you can shed some light on this intriguing discovery.
TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.
Razavi R, Chan Y, Afifiyan FN, Liu XJ, Wan X, Yantha J, Tsui H, Tang L, Tsai S, Santamaria P, Driver JP, Serreze D, Salter MW, Dosch HM.
Neurosciences and Mental Health Program, The Hospital for Sick Children, Research Institute, University of Toronto, Toronto, ON, Canada, M5G 1X8.
In type 1 diabetes, T cell-mediated death of pancreatic beta cells produces insulin deficiency. However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas remains unclear. We report that TRPV1(+) pancreatic sensory neurons control islet inflammation and insulin resistance. Eliminating these neurons in diabetes-prone NOD mice prevents insulitis and diabetes, despite systemic persistence of pathogenic T cell pools. Insulin resistance and beta cell stress of prediabetic NOD mice are prevented when TRPV1(+) neurons are eliminated. TRPV1(NOD), localized to the Idd4.1 diabetes-risk locus, is a hypofunctional mutant, mediating depressed neurogenic inflammation. Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks. Concordantly, insulin sensitivity is enhanced in trpv1(-/-) mice, whereas insulitis/diabetes-resistant NODxB6Idd4-congenic mice, carrying wild-type TRPV1, show restored TRPV1 function and insulin sensitivity. Our data uncover a fundamental role for insulin-responsive TRPV1(+) sensory neurons in beta cell function and diabetes pathoetiology.
As I understand it, the autoimmune theory could be wrong, and the new theory of diabetes type 1 is that the islet cells and nearby sensory neurons are merely inflamed. Injecting capsaicin depletes substance P, which results in a blockade of neurogenic inflammation and restoring these cells to normalcy. I have no idea what I'm talking about. I hope that you guys can help me figure this out, because I know that the sickness industry will not investigate this possible cure. There were studies in Canada of capsaicin injections into the pancreases of type 1 diabetic rats curing them instantly. . .a few years ago. My guess is that they were bought-out or shut-down, because diabetes is a really profitable disease to have around. There's no way that there will be further trials into this, because capsaicin isn't patentable.