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  1. #1
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    I started taking inositol last Friday (6-9 grams per day) to combat the sudden onset of anxiety (possibly pure-O OCD) I've experienced in the past couple of weeks and the depression that has resulted from it. It seems to have helped in both respects, but now I feel pretty spacey. I tend to zone out a lot during the day and in general I don't feel completely "here".



    The truth is, though, I can't really tell if I'm truly "spacey" and "not all there" or if that's just what it feels like relative to the past couple of weeks of hellish anxiety that I've felt. In other words, I might actually be "normal" but it just feels like I'm spacey because of the anxiety and depression of the past couple of weeks.



    Has anyone else experienced this? What are your thoughts?



    Might it indicate my dosage is too high, or maybe even that serotonin is not my problem?

  2. #2
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    Although this is in no way contributing to this thread, I'm really interested to see the responses. Inositol remains to be one of the few supplements that had absolutely zero effect on me... Other than diarrhea, when consuming 2 tablespoons per day.

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    Inositol's mechanism of action in treating depression and OCD-like symptoms is still somewhat unknown, as with most antidepressant agents. Myo-inositol is converted to phosphatidylinositol, which is subsequently converted to various other metabolites with varying effects on the nervous system. For example, inositol-1,4,5-triphosphate is known to regulate intracellular calcium levels in neurons, which may help balance the neurochemical excitation/inhibition levels in the CNS. Another metabolite, diaglycerol, regulates protein kinase C levels. The net effect of these metabolites seems to be an indirect regulation of serotonin receptor sensitivity via inositol's hypothesized second-messenger activity.



    From personal experience, I can say that I need at least 12 g a day to notice any effect from inositol in the realm of antidepressant usefulness. Some researchers say that inositol exerts it's antidepressant effect via a similar mechanism of action as lithium, which would certainly help explain the mental "spaciness" effect, which I have also experienced.



    I tend to think of inositol as a kind of "brain nutrient", like phosphatidylcholine or phosphatidylserine, in that it provides the basic necessary structural component of neuronal cells.
    "When men are most sure and arrogant they are commonly most mistaken, giving views to passion without that proper deliberation which alone can secure them from the grossest absurdities." - David Hume

  4. #4
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    Sir Savage
    I started taking inositol last Friday (6-9 grams per day) to combat the sudden onset of anxiety (possibly pure-O OCD) I've experienced in the past couple of weeks and the depression that has resulted from it. It seems to have helped in both respects, but now I feel pretty spacey. I tend to zone out a lot during the day and in general I don't feel completely "here".



    The truth is, though, I can't really tell if I'm truly "spacey" and "not all there" or if that's just what it feels like relative to the past couple of weeks of hellish anxiety that I've felt. In other words, I might actually be "normal" but it just feels like I'm spacey because of the anxiety and depression of the past couple of weeks.



    Has anyone else experienced this? What are your thoughts?



    Might it indicate my dosage is too high, or maybe even that serotonin is not my problem?


    I would be interested in feedback here as well. I to have been taking inositol at about 6-10 grams a day to help with depression and anxiety. I agree that is has helped me so far since i started taking it last week. I have not experienced what you have described though. I take it on an empty stomach with the dosage divided over 3x daily and i just get a calm and relaxed feeling.



    I am not sure why you don't feel completely "here" though. Are you stacking it with anything else? I have stacked it with L-theanine 300mg and Bacopa monnieri 350mg and i definitely felt a greater intensity in the calmness and relaxation. I did this only in the evening a few hours before bedtime. A bad stacking experience that i had was stacking it with GABA at 2 grams about an hour before bed. BAD IDEA. I almost had an anxiety attack and had to calm myself down.

  5. #5
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    I used this for the same reason w/not much to show for it,but i can second Dopamine's comment about needing 12 grams for it to work,that is if it does work for you.



    I remember that Spook brought this to my attention back when he posted under JM1039 or whatever,which was a while back so I'm sketchy on the details.



    He basically said it worked for his anxiety and was surprised how effective it worked.
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    I have used a 4 to 1 ratio of GABA:INOSITOL works really well, similar to a valium. 2000:500(i think)

  7. #7
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    Here's some suggestions on supps that might help you out:



    bacopa

    rhodilia

    inositol

    epa (get a formula WITHOUT dha as dha saps a lot of epa's bennies on brain function)around 3 grams

    piracetam

    alcar

    choline



    Not sure about dosages for most of these but the articles on BN would give you that.I'd get them in bulk powder and cap them,won't be too expensive.
    Pile of data cannot be equated to the irrefutable truth, no more than a mountain of shit can be scaled to bring one closer to enlightenment.

    No bro-science at Purus because we heart Pubmed and all its peer reviewed studies just too damn much to cheat you with overblown hype.

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    Magic, nope, not stacking it with anything else. Like I said, though, what I'm experiencing may be attributable to the fact that I haven't felt this calm in a good two weeks, making it seem as though I'm spacey. It's hard to say for sure one way or the other.



    The good news is that my anxiety has taken a serious beating, but the bad news is the perceived spacey(i?)ness and seeming lack of much emotion.



    Colin, I think you might be on to something. I probably need to get back on my nootropics.

  9. #9
    Senior Member methodice's Avatar
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    mate



    inositol hit me hard the first time i had it. only 1-2 grams and I felt like I was on something nice, yet i wasn't that relaxed. taking it the day after just made me feel a bit spacey and a bit drowsy.



    dont seem to like it, but I will give it a go later I guess.
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    Sir Savage Posted Yesterday, 06:04 PM
    Magic, nope, not stacking it with anything else. Like I said, though, what I'm experiencing may be attributable to the fact that I haven't felt this calm in a good two weeks, making it seem as though I'm spacey. It's hard to say for sure one way or the other.



    The good news is that my anxiety has taken a serious beating, but the bad news is the perceived spacey(i?)ness and seeming lack of much emotion.



    Colin, I think you might be on to something. I probably need to get back on my nootropics.


    At least you found something that has worked to an extent. I agree with colin also about his reccomendations. I haven't tried rhodilia or ALCAR but the combo of like i said L-Theanine and Bacopa is really good. The past two nights when i have taken it i have had a relaxing evening. Evening time is when i usually get my anxiety the worst. Hope you can get your situation worked out.

  11. #11
    Senior Member trouble's Avatar
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    I use it with Bacopa and GABA. I take it in small doses (1.5 gr) several times per day. I use GABA at about 1 gram, doses throughout the day, and Bacopa at 200-300mgs (morning and then again at night).



    I never take large single doses of inositol. I try to build up and maintain an amount that is calming. but not sedating. Ditto with GABA and Bacopa.



    I cease use of GABA by 6pm, sometimes earlier. Ditto with theanine, when I use it, I use it several hours before bed.
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    i take it 2000mg twice a day

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